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These substrates can be plant allelochemicals, pesticides, environmental pollutants, or byproducts of oxidative stress [40, 42]

Outcomes from the July 23, 2026 PCAC meeting will materially change this section

Trial subjects reported improved skin hydration within 1-2 weeks, noticeable texture and firmness improvements at 4-8 weeks, and reduced fine lines with better skin resilience at 8-12+ weeks

Furthermore, Fra-1 participates in EMT in cancer cells by driving the expression of EMT-inducing transcription factors [49]

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