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The simultaneous interaction with the endogenous Ub-E2-E3 complex and the protein of interest results in the generation of an Ub-E2-E3-neosubstrate complex, ultimately leading to ubiquitinylation and degradation of target protein
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REFERENCES 1 BadenJ.AdamsS.AstacioT.JonesJ.MarkiewiczJ.PainterJ.et al (2011)
The product values were calculated on HPLC peak areas and integrated with OriginPro 8.5 software (Northampton, MA, USA)
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