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Clinical laboratory tests Hormonal and biochemical assessments were carried out for all patients participating in the study in the Royan Institute laboratory
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Therefore, the levels of cytokines (IL-6, IL-12, TNF-) in the macrophage supernatant were detected using an ELISA assay (Fig
Single-Dose Durability: In the Phase 1 single-ascending-dose study, the pharmacokinetic profile supported once-weekly dosing, and a reduction in body weight persisted up to day 43 after a single dose pharmacodynamic effects outlasting even the multi-day plasma presence (PMID 35985340)
MS method development: Poor ionization efficiency and fragmentation can hinder accurate quantitation and structural elucidation, necessitating optimized MS methods tailored to peptide behavior
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