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The PDMS-hydrogel hybrids and pure hydrogel models already described overlap with this definition of the OOAC technique

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Methylene-THF dehydrogenase 2 (MTHFD2) is subsequently responsible for the production of 10-formyl-THF, which is mostly exported and regenerated in the cytosol to participate in purine biosynthesis (Yang and Vousden, 2016)

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