Tirzepatide demonstrated 14.2% FFML in SURPASS-2 and 28.7% in SURMOUNT-1, whereas semaglutide ranged from 11.6% to 40.3%, largely reflecting differences in patient populations, treatment duration, diabetes status, baseline adiposity, and methodology
This indicates that patients may still experience the appetite regulation benefits of GLP-1s, even at lower doses, and the effects may be more gradual and gentler, which could be beneficial for long-term adherence
The FDA shortage designation for both GLP-1s was resolved in early 2025 tirzepatide in December 2024, semaglutide on February 21, 2025 and by May 22, 2025, large scale compounding was legally prohibited
These are absolute or relative contraindications to GLP-1 therapy. Hartwater vs
Some have also been approved for weight management in adults with obesity or overweight with weight-related comorbidities