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Physiology, sleep stages
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SURMOUNT-4 (Aronne et al., JAMA 2024) and a 2025 post-hoc analysis showed that cardiometabolic parameters that had improved on tirzepatide blood sugar, blood pressure, lipids, and weight largely reversed toward baseline after stopping, in proportion to the weight regained
Polyzos SA, Goulas A, Papaioannidou P
Relying solely on the appetite suppression of semaglutide without a structured nutrition strategy is a mistake
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