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In practice, if a therapy is considered, success should be defined with measurable endpointssleep quality, function, waist circumference/body composition (when appropriate), and metabolic markersrather than vague claims alone

For men on semaglutide, having a greater percentage of body fat was associated with successful weight loss at a six-month follow-up

It takes approximately this long for daily dosing to reach a pharmacokinetic equilibrium, where the rate of drug accumulation from daily dosing matches the rate of elimination

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Black coffee contains negligible calories, but adding sugar, full-fat milk, cream, or flavoured syrups can significantly increase caloric intake, potentially undermining weight loss efforts