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The Problem: Standard melatonin is often too weak to override this powerful alert signal

Strongly associated with other autoimmune diseases and a family history of autoimmunity

Contraindications and precautions Consider avoiding DSIP or consulting a physician if: Pregnant or breastfeeding (insufficient safety data) Taking naloxone or other opioid antagonists (may block effects) Using medications metabolized by peptidases (potential interactions) History of immune disorders (theoretical immunogenicity concern) Already using multiple sleep medications Drug interactions Because DSIP degrades via amino-peptidases in blood, medications affecting these enzymes (like the ACE inhibitor captopril) could theoretically alter DSIP metabolism

Larger, controlled studies are needed to validate these findings and assess their broader clinical applicability