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Practical takeaway Until stronger evidence exists, the review argues the path forward is collaborative pregnancy registries + better real-world data, so inadvertent exposures can be counselled with confidenceand so we can finally test whether pharmacotherapy could ever play a role in carefully selected high-risk cases

(Eli Lillys pill Foundayo led to the same rate of weight loss in a Phase 3 study that lasted twice as long, but its hard to compare across trials in different phases.) In a separate Phase 2 trial in people with diabetes, called SOLSTICE, patients on the highest dose saw up to a 1.74 percentage-point decrease in a measure of blood sugar called A1C after 26 weeks

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There is increasing interest in SGLT-2 inhibitors for treating acutely ill patients