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And the expression of downstream gene significantly reduced after treated inhibitors of PI3K, Akt, and mTOR

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The primary role of HSPs is to protect cells by aiding in proper protein folding, preventing the aggregation of damaged peptides, and enhancing cell survival [89]

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The RPKM (reads per kilo base per million mapped reads) table was generated, and differential gene expression analyses were carried out with the webserver pipeline T-Rex 54 on the Genome2D webserver ( The significance threshold was defined by a p-value of 2 (TopHits in T-REx)