NAMPT and NRK1/2 are also localized to the nucleus and cytosol 48,83,84 , suggesting that only the final step of salvage is performed in the mitochondria, with a mitochondrial NMN transporter, Slc25a45, recently proposed 85
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However, specific patient populations such as individuals with mutations in their glutathione synthesizing enzymes, AIDS patients, and cystic fibrosis patients can benefit from glutathione supplementation (Ashley, 2018)
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