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Two clinical signatures follow: a measurable rise in resting energy expenditure (REE) independent of caloric deficit, and substantial reductions in intrahepatic lipid

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If you have documented B12 deficiency or absorption issues, the combination could provide genuine benefit

Regain begins within 4 to 6 weeks of last dose Appetite increases but remains below pre-treatment baseline Weight regain of 0.5 to 1 pound per week for 12 to 16 weeks, then plateau Patients report maintaining some dietary changes learned during treatment Net long-term outcome: retain 30 to 50% of weight lost on medication Typically occurs in patients who built structured meal patterns and exercise habits during treatment Pattern 3: Sustained maintenance without medication (approximately 15% of discontinuations)

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