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Tirzepatide is a dual GIP and GLP-1 receptor agonist , meaning it activates receptors responsive to two different incretin hormones: glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-1 (GLP-1)
Semaglutide works by mimicking a naturally occurring GLP-1 hormone involved in appetite regulation and metabolic function
JAMA Network Open, 7 (5), e2413172
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Animal experiments also suggest that liraglutide has a neuroprotective effect in murine models of Parkinson's disease (PD), which is accomplished by activating PGC-1 to regulate mitochondria biogenesis, dynamics, autophagy, and apoptosis in substantia nigrathe region in the brain that gets damaged by PD [22]
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