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The more likely culprit is the weight loss itself
Image credit: Pixel-Shot/Shutterstock.com After analyzing evidence from trials involving more than 8,000 people, researchers found that GLP-1 weight-loss drugs were linked to lower binge-eating severity, reduced loss of control around food, and less disinhibited eating in adults with overweight or obesity
Simply, because L-citrulline gets absorbed by the stomach much easier than arginine
"GHK influenced the expression of about 4,000 human genes, shifting their expression from a diseased or aged state toward a healthier profile." Pickart et al., BioMed Res Int (2014) Loading, Tapering, and Continuous Use# There is no loading phase
Safety Monitoring Recommendations Based on the available clinical trial data, clinicians prescribing orforglipron should: (1) counsel patients about expected GI side effects during dose escalation, (2) follow the recommended dose-titration schedule to minimize GI intolerance, (3) monitor for signs of pancreatitis and discontinue if suspected, (4) assess hepatic and renal function at baseline and periodically, (5) screen for personal or family history of MTC or MEN 2, and (6) review concomitant medications for potential CYP3A-mediated drug interactions
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