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As an engineered analogue, cagrilintide is designed to mimic key receptor-binding properties of native amylin while incorporating structural modifications that extend its activity and stability in experimental systems
In another study where many research investigations were summarized, while patients reported earlier pain improvements with surgery, there were indications that the patients who had surgery did worse on residual hip pain and function in the long run (8)
While preclinical human studies support its safety and receptor selectivity, caution remains essential due to its systemic effects on metabolism
PMID: 14 ZhangDD
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