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While it has not been conclusively established whether this dysfunction is a cause or consequence of the pathological processes, growing evidence suggests that reduced proteasomal activity may contribute to the accumulation of toxic protein aggregates and the progression of neurodegeneration

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This is a good sign that your treatment is working, even if some symptoms are still improving

The FDA has specifically evaluated it as a bulk drug substance for compounding and raised questions about its safety profile and the adequacy of available data