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Indeed, the PDH complex, which decarboxylates glycolytically derived pyruvate to acetyl coenzyme A and links cytoplasmic glycolysis to the mitochondrial tricarboxylic acid (TCA) cycle, is modulated by reversible phosphorylation by PDH kinase (PDK)
Full results, especially for deeper pigmentation and melasma , typically appear after six to eight weeks
She adds that starting with a lower dose of 2 mg/week instead of 4 mg/week may help mitigate adverse effects
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