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Limitations: Vision-specific research very limited

The easiest way to understand how this works is to envision the IGF-1 receptor as a lock and IGF-1 LR3 as the key

1991, 39, 309310 Low-Beer, etal, 1968 Serum vitamin B12 levels and vitamin B12 binding capacity in pregnant and non-pregnant Europeans and West Indians PMID 5681054 Krishnaveni etal, 2009 Low plasma vitamin B12 in pregnancy is associated with gestational 'diabeity' and later diabetes

They target different receptors and were designed to be complementary which is exactly why cagrilintide is studied in combination with an incretin (semaglutide) rather than against one

Nat Struct Mol Biol 21(2):167174