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However, a 2021 study by Sun et al
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Quality-control risk Because there is no FDA-approved AOD-9604 product, all material in circulation comes from research-supply or compounding sources
Its working mechanism is allosteric facilitation of HGF/c-Met signaling: Dihexa binds HGF with high affinity (reported K d ~65 pM in the original work) and is proposed to potentiate HGF dimerization and c-Met phosphorylation at subthreshold endogenous HGF concentrations
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