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The peptide binds to GHRH receptors and activates receptors on pituitary somatotrophs, initiating cAMP-mediated intracellular signaling that stimulates physiological GH secretion and produces secondary IGF-1 elevation through hepatic stimulation

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Natural amylin slows gastric emptying, suppresses glucagon secretion, and activates receptors in the area postrema and nucleus of the solitary tract

10.2174/13816128130111 128 SikiricP.SeparovicJ.AnicT.BuljatG.MikusD.SeiwerthS.et al (1999a)

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