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Mechanisms of disease: endothelial dysfunction in insulin resistance and diabetes
Aronne LJS, Horn N, He DBB, et al
453,454 Moreover, losing just 5%7% of body weight can prevent or delay 60% of diabetes and ameliorate insulin sensitivity in obese and overweight individuals
In integrated transcriptomic and single-nucleus RNA sequencing (snRNA-seq) analyses, necroptosis was identified as a highly enriched RCD pattern in DKD tubules, defining distinct patient subtypes that correlate closely with chronic inflammatory responses and macrophage infiltration (229)
PubMed, Dragovic, Sanja, et al
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