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The reason insulin therapy and drugs like tirzepatide cant be taken orally in pill form is because they are peptides
Increasing evidence suggests that GLP-1R plays a critical role in maintaining cell metabolism homeostasis by improving mitochondrial function [56, 57]
As only a subset of candidates was validated, additional GLP-1RAs may also be capable of activating the cAMP second messenger signaling pathway
GLP-1 RAs offer improved glycaemia, weight loss and cardiovascular benefits in those for whom they are recommended by the guidelines, so it is important that we facilitate their initiation and continuation in as many appropriate people as possible
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