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PepT1-Mediated Tripeptide KPV Uptake Reduces Intestinal Inflammation
HDACi reduce HIF output by blocking HIF transactivation and/or lowering HIF-1 protein (often via translational control) (201203), while BET inhibitors (e.g., JQ1, OTX015/MK-8628, molibresib, pelabresib) limit recruitment of BRD proteins to hypoxia-responsive promoters, diminishing expression of HIF target genes like CA9 and VEGFA (204, 205)
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Two years ago, researchers examining the link between GLP-1 and substance abuse began to publish large, observational studies showing that patients taking GLP-1s for their prescribed purposes incidentally reported less alcohol, opioid, cannabis and cigarette use and had a lower risk of developing a substance use disorder
Insights from a mediation analysis of the EMPA-REG OUTCOME trial
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