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The first step is catalyzed by glutamate-cysteine ligase (GCL), which is composed of catalytic and modifier subunits (GCLC and GCLM)

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Consequently, targeted inhibition of GPX4 represents a core therapeutic strategy for inducing ferroptosis in GBM cells

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Access this chapter Similar content being viewed by others References Sweeney AR, Gupta D, Keene CD, et al

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