Treatment and monitoring of SAGE-DM Currently, there is no specific evidence-based treatment algorithm for SAGE-DM However, the management of SAGE-DM should be adapted from geriatric diabetes guidelines, considering the underlying aging mechanisms that may affect the response to treatment The following recommendations can thus be viewed as an adaptation of standard care within the SAGE-DM conceptual framework rather than a fully validated treatment pathway Monitoring HbA1c may be unreliable in in the elderly due to comorbidities affecting red blood cell lifespan (e.g., advanced kidney disease, GI bleeding, heart valve defects)
The hope is that by reducing the dose, you can still lose weight and keep it off without the side effects like nausea, vomiting, and diarrhea
Improved sleep is one of the changes patients most commonly describe to us, though individual response varies
Factor #3: The birth control absorption concern The theoretical problem works like this: GLP-1s slow gastric emptying by 60-70%, while oral contraceptive pills need to move from stomach to small intestine to be absorbed
Semaglutide targets the GLP-1 receptor alone