Side Effects and the Copper Uglies Explained GHK-Cu has a strong safety profile in topical research, but a small subset of users experience a transient phase known as the copper uglies. A 2023 clinical safety review covering 12 studies and 512 participants reported that the most common side effects of topical GHK-Cu were transient and mild
Activation of NF-B appears from these studies to be critically regulated by intracellular thiol redox status
Loomba R, Hartman ML, Lawitz EJ, Vuppalanchi R, Boursier J, Bugianesi E et al
And its like back in the 90s, I dont know what it was, but it was like some of the lighting too was almost so bad that it gave this granular shark sharp, kind of like pixelated but like etchy look to the physiques
Large human trials (such as the SUSTAIN and STEP programs) have not shown meaningful increases in fracture risk or significant reductions in bone mineral density directly attributable to semaglutide use