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Researchers in the 1940s were apparently following a valuable lead by showing that estrogen is not fully inactivated by the liver if there is a vitamin B deficiency

Cisplatin induces BDNF downregulation in middle-aged female rat model while BDNF enhancement attenuates cisplatin neurotoxicity

Additionally, one clinical study reported that consumption of chlorogenic acid-enriched coffee not only improved plasma antioxidant capacity and decreased plasma lipid and protein oxidation but also donated to enhancing cardiovascular health in people with hypercholesterolemia [169]

[1] The authors framed the observed metabolic shifts as a direct effect on lipid handling in the model rather than appetite suppression