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According to the American Society for Metabolic and Bariatric Surgery, surgical patients lose up to five times more weight at two years compared to those using semaglutide or tirzepatide, with sustained benefits for a decade or more, whereas most medication users regain weight once treatment stops

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The peptide's anorexigenic effects appear mediated primarily through MC4R, as studies using MC4R-specific agonists produced similar appetite-suppressing effects

Diabetes 51, 439442

Change history 23 March 2017 A correction has been published and is appended to both the HTML and PDF versions of this paper