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Tumor-derived extracellular vesicles, including exosomal circRNAs, disrupt miRNA networks in T cells, promoting exhaustion and loss of effector function
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Its mechanism is highly targeted, ensuring that the release of growth hormone is precise, without significantly increasing levels of cortisol or prolactin, which can cause unwanted side effects
Glutathione S-transferase (GST) fusion proteins (Rab interacting lysosomal protein (RILP)-C33-GST, GST-perfringolysin (GST-PFO)) were produced in E.coli BL21 cells and purified using glutathione Sepharose 4B beads (GE Healthcare) as described [12]
Frontiers in Pharmacology, 13, 1026182
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