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If cells become resistant to insulin, the blood glucose is stored as fat instead of used for energy, which causes weight gain instead of weight loss

This diversity strengthens the generalizability of the safety data, suggesting the findings should apply broadly across different population groups

Glucagon receptor agonism: Promotes energy expenditure and hepatic lipid metabolism through thermogenesis

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The Ottawa Hospital Sterne JA, Hernn MA, Reeves BC et al (2016) ROBINS-I: a tool for assessing risk of bias in non-randomized studies of interventions