glp 1 receptor agonist heart failure Updated evidence on cardiovascular and renal effects of GLP-1 agonists and combination therapy with SGLT2 inhibitors and finerenone: a narrative review and perspectives | Cardiovascular Diabetology Efficacy of GLP‐1 receptor agonists

IDF, 2021

The AAFP advises that injectable therapy leads to more rapid improvement and should be considered in patients with severe deficiency or severe neurologic symptoms (Langan RC, Goodbred AJ, 2017)

Here's the quick version: For a 10mg vial: Add 2mL of bacteriostatic water (BAC water) this gives you 5mg/mL For a 0.25mg dose: draw 5 units (0.05mL) on a U-100 insulin syringe For a 0.5mg dose: draw 10 units For a 1mg dose: draw 20 units For a 20mg vial: Add 4mL BAC water same 5mg/mL concentration, same dose math above Injection technique: SubQ injection pinch the skin at belly, thigh, or upper arm 31g or 32g insulin needle ( inch length is fine for subQ) Inject slowly, hold for 5 seconds before withdrawing Refrigerate after reconstitution stable 4-6 weeks in the fridge Realistic Expectations for Weeks 1-12 Here's what most people experience on a conservative titration, assuming reasonable diet and some exercise: Weeks 1-2: Minimal weight change

If six months of consistent, properly-dosed application produces no noticeable change, alternative approaches may be needed

Diet for Epilepsy Ketogenic Diet A Michigan pediatrician first described the ketogenic (keto) diet in the 1920s