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Retatrutide is an investigational triple agonist that simultaneously targets three hormone receptors: glucagon-like peptide-1 (GLP-1), glucose-dependent insulinotropic polypeptide (GIP), and glucagon receptors

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Further, inclusion of the safety measures in the first study, even though they were burdensome, helped validate the safety of these medications in individuals with an opioid use disorder

The most common side effects are gastrointestinal and stomach issues like diarrhea, gassiness, constipation, nausea, and vomiting

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