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Substances under S0 are classified as non-Specified Substances under the WADA Code, with sanctions of two to four years applied on a positive sample depending on intent findings

Due to the compounds plasma half-life of approximately 3.86.9 hours [4] , twice-daily (BID) dosing may provide more sustained NNMT inhibition

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Second, restricts distribution and is subject to active efflux, yielding heterogeneous brain exposure across regions and patients