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For chronic weight management, both trizepatide (Zepbound) and semaglutide 2.4 mg (Wegovy) are indicated for adults with a BMI 30 or a BMI 27 with at least one weight-related condition (such as hypertension, dyslipidemia, type 2 diabetes, sleep apnea, or cardiovascular disease)

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The essential role of IGFs in cell growth is shown by the report that fibroblasts from IGF-1 receptor knockout mice grew very slowly in culture unless they were transfected with a plasmid expressing the IGF-1 receptor