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Preclinical studies in rodent models have consistently demonstrated that GLP-1 agonists decrease alcohol consumption, reduce alcohol-seeking behavior, and prevent relapse-like drinking after periods of abstinence

Two studies using vildagliptin and sitagliptin have examined the impact of DPP4 inhibition on the kidneys of hyperglycemic animal models, demonstrating renoprotective effects

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Compounded semaglutide and side effect differences Compounded semaglutide is prescribed by many providers as an alternative to brand-name formulations

This study population was then divided into 3 cohorts: (1) semaglutide cohort 1470 patients who were first-time prescribed semaglutide, (2) non-GLP1-RA anti-obesity medication cohort 2784 patients who were first-time prescribed non-GLP-1RA anti-obesity medications but not semaglutide and (3) naltrexone/topiramate cohort 1430 patients who were first time prescribed naltrexone and topiramate but not semaglutide