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Start your intake Why GLP-1 Doses Start Low and Increase Gradually GLP-1 receptor agonists slow stomach emptying and reduce hunger signals in the brain, but the body needs time to adjust to these effects

The challenging period is finite and worth enduring for those who can manage it

Once symptoms resolve, patients may be cautiously rechallenged using the previously tolerated dose, with slower subsequent escalation or extended titration intervals

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Twice-daily exenatide (Byetta) requires more specific timing: it should be administered within 60 minutes before the two main meals of the day (typically breakfast and dinner), at least 6 hours apart