Thats where a melatonin supplement can be handy, to give it that nudge
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When insulin resistance occurs, mitochondrial-related protein levels change, mitochondrial membrane potential decreases, calcium homeostasis is disrupted (29), and reactive oxygen species (ROS) production increases, leading to cell death
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For liver and kidney safety, both drugs may cause dehydration due to nausea and vomiting, which can lead to kidney problems