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Semin Thromb Hemost
In bone, GIP promotes bone formation while GLP-1 inhibits bone absorption
Newer drugs like Mounjaro (Tirzepatide) combine GLP-1 and GIP (Glucose-Dependent Insulinotropic Peptide) effects
In keeping with the reduced capacity of homocysteine-exposed endothelial cells to inhibit platelet aggregation, Lentz and collaborators demonstrated, using experimental hyperhomocysteinemia (induced by a diet depleted of folate, high in methionine, and choline-free) that the endothelial-dependent vasodilation is impaired in hyperhomocysteinemic primates
Chemoresistance remains a major obstacle in improving responses to BTC treatment, and new drug combinations offer promising innovations to BTC patients
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