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Three main paths exist: Weeks 37-48 Summary: Completion and Planning Weight loss: 3-7 pounds this period (49-53 pounds total, ~24% of starting weight average) Weekly loss rate: 0.25-0.6 pounds weekly (minimal but still progressing) Final results: 24.2% average total body weight loss by week 48 Discontinuation rate: 1-2% during this period Overall completion rate: 74% of people who started week 1 completed week 48 Psychological state: Proud of achievement, planning next steps What Actually Determines Your Timeline Results Individual timelines vary from the averages presented
However, recent FDA updates may limit the availability of these compounded medications, which could lead to higher prices and restricted supply
Metabolic adaptation is the primary driver of this deceleration
Readout is also expected in Q2-Q3 2026
Pathophysiology of diabetic kidney disease and therapeutic targets of sodium-glucose cotransporter 2 (SGLT2) inhibitors and glucagon-like peptide-1 (GLP-1) receptor agonists
