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Further compounding the problem is the absence of sufficient patient persistence on the drugs: A relatively large portion of patients discontinue these medications within one year , with numbers increasing by the end of years two and three

then a 20 mg/kg dose (the typical therapeutic dose) produces a gut concentration of 6000 M, assuming 75% bioavailability

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co-supplementation with vitamin A and iron seems to ameliorate anemia more effectively than either micronutrient supplement alone (71)

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