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In recent years, advances in cryo-electron microscopy (cryo-EM) have enabled structural determination of a large number of class B1 GPCRs bound to their endogenous agonists, and coupled to G s , including that of the GLP-1R, which confirm engagement of these peptides with both the ECD and the TMD 10,11,12,13,14,15,16,17,18,19,20,21

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Obesity is widespread in the U.S., affecting 42.4% of adults (over 140 million Americans), with 9.2% classified as severely obese (over 30 million Americans)

Bibcode:1993Sci...261.1047D