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Mitochondria contain multiple copies of their own genome, mitochondrial DNA (mtDNA), which encodes for 13 polypeptides of the OXPHOS and respiratory chain, as well as two ribosomal RNAs and 22 transfer RNAs necessary for translation of polypeptides inside mitochondria

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Both changes sit in the region that IGF binding proteins recognise, so the analogue binds IGFBPs far more weakly than IGF-I while retaining high affinity at the type 1 IGF receptor

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Gastrointestinal absorption of vitamin B 12depends on the presence of sufficient intrinsic factor and calcium ions