Reactive nitrogen species in cellular signaling
Patients should also contact their provider promptly if they experience: Persistent or worsening nausea and vomiting lasting more than a few days Inability to maintain adequate oral intake of food or fluids Symptoms of hypoglycemia (shakiness, sweating, confusion, rapid heartbeat), particularly if taking tirzepatide with insulin or sulfonylureas Signs of allergic reaction, including rash, itching, swelling, or difficulty breathing Changes in vision or symptoms of diabetic retinopathy progression, especially with rapid improvement in blood glucose New lump or swelling in the neck, hoarseness, or difficulty swallowing (potential thyroid tumor symptoms) Routine follow-up should address less urgent concerns such as persistent mild nausea affecting quality of life, ongoing constipation or diarrhea, injection site reactions that don't resolve, or questions about dose adjustment

The STEP 1 trial of semaglutide showed average weight loss of 14.9% of body weight at the 2.4mg dose over 68 weeks in people without diabetes
I am taking a GLP-1 weight-loss medication what should I know? July 14, 2025
Seek immediate medical attention (call 999 or attend A&E) if you experience severe dizziness with loss of consciousness, chest pain or shortness of breath, severe persistent vomiting or diarrhoea with dehydration, neurological symptoms (slurred speech, visual disturbances, weakness), or severe abdominal pain that could indicate pancreatitis