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Life happens the cost becomes unsustainable or insurance drops coverage
In the absence of MPC activity, import of pyruvate into the mitochondria is greatly diminished, meaning that less acetyl-CoA can be produced by pyruvate dehydrogenase and therefore that TCA cycle flux is diminished (Gray et al., 2015
The drugs come with list prices that can top $1,200 a month , although health insurance companies often negotiate deep discounts
These real-world results give new patients confidence to act quickly
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