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KPV acts directly on MC1R/MC4R receptors on macrophages and epithelial cells, reducing IL-6 and TNF- at the transcription level [7,8]
In the lower intestine, microbial strains have been reported, that are involved in the breakdown of procyanidins into catechin and epicatechin monomers which are thereafter transformed into phenylvalerolactones such as 5-(3,4-dihydroxyphenyl)--valerolactone
So theres a bunch of reasons that people might want towell, Ill say this
& Yamamoto, T
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