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Experimental Protocol In deeply anesthetized rats (intraperitoneal (ip) injected 40 mg/kg thiopental (Rotexmedica, Germany) and 10 mg/kg diazepam (Apaurin
Another is in vivo confocal microscopy of fluorescent dextran (MW ~ 10 kDa) that when injected intravenously penetrated the intercellular junctions up the region of the tight junctions
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Per ECHA convention in the DEHP risk assessment, since the main degradation product MEHP is of toxicological relevance, it is not appropriate to calculate the environmental half-life based on primary degradation rates. Reading DOP biodegrades fast as parent disappearance and reading it as full mineralisation through MEHP give two different regulatory verdicts on the same number
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