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Lipid-Lowering Therapies Traditional lipid-lowering therapies statins, ezetimibe, proprotein convertase subtilisin/kexin type 9 (PCSK9) inhibitors, inclisiran, and bempedoic acid primarily reduce circulating apolipoprotein B (ApoB)containing lipoproteins, which both retards new atherogenesis and, at sufficient magnitude, drives angiographic plaque regression [15][17]
The next generation of GLP-1s, which is expected to be launched next year, may demonstrate amplified effects that could include improved neuroprotection, Thiara says, but its impact would need to be validated through rigorous clinical trials, she stated
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during the March 2023 to September 2024 time frame is better but far from encouraging
This highlights the potential impact of effective treatment for obesity in improving long term outcomes, especially when combined with other lifestyle interventions such as diet and exercise changes
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