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[2] acetylcysteine Acetylcysteine will address the underlying pathophysiological causes of pyroglutamic acidosis (deficiencies of glutathione and cysteine)
Modern liver-specific IGF-1 knockout studies have shown that local IGF-1 contributes substantially to tissue IGF1R activation, separate from the endocrine pool
When both are active simultaneously, IGF-1 is rising from the GH-axis stimulation while local collagen synthesis is also being supported
The underlying mechanism is TD-induced impairment of PDHC activity, which causes remodeling of glucose metabolism in the macrophages
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