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Aged C57BL/6J mice (18-24 months) : more naturalistic model, slow but robust, ideal for long-term studies on Semax or Selank

The FDA-approved titration schedule for Wegovy starts at 0.25 mg weekly for four weeks, then increases to 0.5 mg, then 1.0 mg, then 1.7 mg, and finally the maintenance dose of 2.4 mg