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Notice that GSH goes up for low estradiol values, reaches a peak and descends for high estradiol values Variation of GSH steady state depending on S In our model, we take the activation of GCL and GPX by estradiol to be 80%, which is a reasonable choice supported by the experimental and clinical data discussed above
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Biochem Pharmacol 2009
Liver Health (SYNERGY-NASH) Loomba R, Hartman ML, Lawitz EJ, et al
2008 May;57(5):712-7
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